Systems and methods for patient cardiovascular and respiratory management

ABSTRACT

An information display and control system that enables a fast and easy understanding and management of the status of the patient&#39;s dialysis is disclosed. Also disclosed is an information display and control system that enables a fast and easy understanding and management of the status of the patient&#39;s cardiovascular and ventilation systems. The system can control management of a patient&#39;s dialysis, as well as administration and management of a patient&#39;s medication and fluids. The display is organized by goals related to management of patient&#39;s dialysis machine, blood flow, dialyzer flow, and patient&#39;s body weight. The display is also organized by goals related to management of patient&#39;s cardiovascular system, ventilation system, and medications and fluids administration and management. Such goals include urea reduction rate, urea reduction ratio, fractional urea clearance, total urea reduction, dialysis treatment duration, hemodynamics, oxygenation, CO 2  removal, medication status, and fluids status.

CROSS REFERENCE TO RELATED APPLICATION

This application is a continuation-in-part of U.S. patent application Ser. No. 16/201,930, filed on Nov. 27, 2018, which is a continuation-in-part of U.S. patent application Ser. No. 12/764,031 filed on Apr. 20, 2010, now U.S. Pat. No. 10,136,813, which is a continuation-in-part of International Application No. PCT/US2008/080564 filed Oct. 20, 2008 which claims the benefit of priority to U.S. Provisional Application No. 61/000,150, filed Oct. 20, 2007, all of which are incorporated herein by reference in their entireties.

TECHNICAL FIELD

The present invention relates to management, display and information presentation and decision-support systems used to improve attention allocation, situation awareness, problem solving and decision making during management of patient's cardiovascular and ventilation systems and during administration and management of patient's medications and fluids.

BACKGROUND

Human error results when available resources of the clinician, such as knowledge, skills, and strategies, are inadequate for the demands of the situation. In medicine, monitoring equipment and their displays extend the physician's resources but at the expense of additional cognitive demands. Clinicians' abilities to meet the demands of critical decision making during management of patient's cardiovascular system and during administration and management of patient's medication and fluids depend not only on their internal resources, but also on the displays through which they perceive the situation. Although some patient and equipment indicators are observed and measured directly by the clinician, increasing, the data used to diagnose and correct critical situations are measured and displayed by medical equipment.

Most medical informational displays are traditional, in that they are based on the one-sensor/one-indicator technology. Research in other domains has shown that such display design is not compatible with the capabilities of the human perceptual system, and may hinder data transmission from the machine to the human. Traditional numeric and meter displays do not take advantage of people's inherent ability to understand patterns and shapes. During routine and problem-solving situations, the human must scan many displays to collect relevant data. Traditionally, data is displayed in a single format, even though the relevance of the data changes with the goals of the situation. Traditional displays have high attention demands since insignificant information may be prominent while important data are pushed into the background. Since traditional displays do not directly display the high-order state of the system, the clinician problem-solver must deduce system state by processing raw data, in the form of machine-sensed variables, directly-sensed indicators, and situational cues. Furthermore, the functional relationships among the various elemental display elements are not represented and calculations are sometimes required to derive such high-order state properties. Traditional displays require considerable effort and knowledge which may exceed the human's capabilities or the time available for effective action.

In other complex domains, new management and display systems, called ecological interface systems, have been developed to reduce human error and support the clinician's attentional and problem solving and decision-making demands. Ecological Interface Design (EID) has been proposed as a method for creating human-machine equipment that make work processes more visible and aid the human during complex management and problem-solving situations. In ecological interface systems, elements are organized to show inter-relationships among system variables. The interface is organized in two dimensions: abstraction hierarchy and system decomposition. In the abstraction hierarchy, the highest level contains operator goals, middle levels represent system functions, and the lowest level specifies the system's controls and physical form. In system decomposition, the highest level represents the whole system, middle levels describe subsystems, and the lowest level deals with components. Thus, the system contains controls and representations of everything the operator needs to consider in performing his or her work, from abstract goals to physical actions, whether dealing with the entire system or considering specific components.

Ecological interface systems present the operator with a complete set of the goals to be achieved in managing the system, the rules or the constraints that govern these goals, and the low-level variables or data that are processed by these rules. By making system processes visible, ecological interface systems support various tasks, such as process control, safety monitoring, and fault diagnosis. Safety monitoring is performed high in the abstraction dimension to detect violated goals. Fault diagnosis is accomplished by moving down the abstraction hierarchy, along the paths of violated goals, to detect the rules that have been broken. Further down the hierarchy are the controls or variables to be manipulated in order to correct the event. Ecological interface systems have been utilized in nuclear and petrochemical process applications, but have not been widely used and applied to medical systems. In this patent application, we apply the EID principles to design a system for management of patient's cardiovascular and ventilation system and for the administration and management of patient's medications and fluids.

SUMMARY

A human-machine system for use for management of patient's cardiovascular and ventilation systems and the administration and management of patient's medications and fluids is disclosed having the capability of design and configuration of a display of the goals and objectives, processes and functions, and components and controls comprising management of patient's cardiovascular and ventilation systems and the administration and management of patient's medications and fluids. The system utilizes several levels of abstraction hierarchies to present to the user goals, middle- and lower-level functional parameters, and lower-level components and controls used in monitoring and controlling the cardiovascular and ventilation systems and in the administration and management of patient's medications and fluids. The system presents to the user:

-   -   1. The higher-level goals and objectives of managing the         cardiovascular and ventilation systems and for the         administration and management of patient's medications and         fluids.     -   2. The middle- and lower-level functional parameters and         variables used during monitoring and controlling the         cardiovascular and ventilation systems and during the         administration and management of patient's medications and         fluids.     -   3. The lower-level components and controls used during         monitoring and controlling the cardiovascular and ventilation         systems and during the administration and management of         patient's medications and fluids.     -   4. The inter-relationships between the goals and objectives, the         functional parameters or variables, and the lower-level         component and controls used for monitoring and controlling the         cardiovascular and ventilation systems and for the         administration and management of patient's medications and         fluids.

The system maps such goals and objectives, functional parameters or variable, lower-level components and controls, and the inter-relationships between the goals, the functional parameters or variables, and the lower-level component and controls onto an anatomical graphical representation of the cardiovascular and ventilation systems. The anatomical graphical representation of the cardiovascular system shows the anatomy or layout of the cardiovascular system and its components including the heart, the systemic and pulmonary arterial and venous vascular systems, the blood, and the circulatory nature and appearance of the cardiovascular system. The anatomical graphical representation of the cardiovascular system also shows animation of the heart's contraction, and the blood flow with the cardiovascular system. The anatomical graphical representation of the ventilation system shows the lungs and animation of breathing or mechanical ventilation.

Furthermore, the system utilizes mass conservation principles to calculate and present to the user information pertaining to balance between the goals and objectives of managing the cardiovascular and ventilation systems within the different parts of the cardiovascular system. The system presents to the user information pertaining to the functional parameters or variable, and the interrelationships between them and the higher-level goals and lower-level controls of managing the cardiovascular and ventilation systems. The system utilizes mass conservation principles to calculate and present to the user information pertaining to balance between the goals and objectives of the administration and management of patient's medications and fluids. The system presents to the user information pertaining to the functional parameters or variable, and the interrelationships between them and the higher-level goals and lower-level controls of the administration and management of patient's medications and fluids. The system provides the user (clinicians, nurses, etc.) with real time data for process monitoring and control of patient's cardiovascular and ventilation systems to support management of patient's hemodynamics, ventilation, and the administration and management of medications and fluids. The system facilitates activities such as attention allocation, situation awareness, abstract reasoning, and hypothesis testing during management of the cardiovascular system and during the administration and management of patient's medications and fluids.

Also disclosed is a human-machine system for use for management of patient's dialysis is disclosed having the capability of design and configuration of a display of the goals and objectives, processes and functions, and components and controls comprising management of patient's dialysis. The system presents to the user goals, middle- and lower-level functional parameters, and lower-level components and controls used in monitoring and controlling patient's dialysis.

The system also controls patient's dialysis parameters including blood flow rate, dialyzer flow rate, patient's body weight, urea reduction rate, urea reduction ratio, fractional urea clearance, total urea reduction, and dialysis treatment duration.

The system maps such goals and objectives, functional parameters or variable, lower-level components and controls, and the inter-relationships between the goals, the functional parameters or variables, and the lower-level component and controls onto an anatomical graphical representation of the dialysis systems. The anatomical graphical representation of the dialysis system shows the layout of the dialysis system and its components including the arterial blood flow from the patient's arterial access in his/her arm, arterial blood pump, blood flow through the dialysis machine, venous blood flow from the dialysis machine to the patient's venous access in his/her arm, the dialyzer and fresh and used dialysate flows, arterial pressure monitor, venous pressure monitor, and dialyzer inflow pressure monitor. The anatomical graphical representation of the dialysis system also shows animation of the arterial and venous blood flows, arterial blood pump motion, and fresh and used dialysate flows through the dialyzer.

The system facilitates control and management of patient's dialysis in clinic or at home, and supports activities such as attention allocation, situation awareness, abstract reasoning, and hypothesis testing.

A method for displaying integrated graphics for control and diagnostics for a patient's dialysis is disclosed. The method comprising displaying a graphic object representing urea performance based on at least one measurement from the patient's dialysis performance, said graphic object including at least a first, second, and third parameter; displaying at least one dynamic graphical line from the first parameter being displayed to the second parameter being displayed, and wherein the displaying of the dynamic graphical line comprises illustrating at least one functional relationship between the first and second parameters; and displaying a Urea Reduction Ratio (URR) graphic object representing the patient's dialysis urea reduction performance, wherein displaying the URR graphic object comprises displaying arterial blood urea concentration (UB_(A)C) and venous blood urea concentration (UB_(V)C). The integrated graphics for control and diagnostics for the patient's dialysis are displayed on one or more machine-generated displays.

A non-transitory readable medium comprising computer-executable instructions stored thereon is also disclosed. The computer-executable instructions instruct one or more processors to display a graphic object representing urea performance based on at least one measurement from the patient's dialysis performance, said graphic object including at least a first, second, and third parameter; display at least one dynamic graphical line from the first parameter being displayed to the second parameter being displayed, and wherein the displaying of the dynamic graphical line comprises illustrating at least one functional relationship between the first and second parameters; and display a Urea Reduction Ratio (URR) graphic object representing the patient's dialysis urea reduction performance, wherein displaying the URR graphic object comprises displaying arterial blood urea concentration (UB_(A)C) and venous blood urea concentration (UB_(V)C).

A method for displaying integrated graphics for control and diagnostics for a patient's dialysis is disclosed. The method comprising displaying a graphic object representing urea performance based on at least one measurement from the patient's Dialysis performance, said graphic object including at least a first, second, and third parameter; displaying at least one dynamic graphical line from the first parameter being displayed to the second parameter being displayed, and wherein the displaying of the dynamic graphical line comprises illustrating at least one functional relationship between the first and second parameters; and displaying a Fractional Urea Clearance (Kt/V) graphic object representing the patient's dialysis urea reduction performance, wherein displaying the Kt/V graphic object comprises displaying the Dialyzer Clearance (K), dialysis treatment duration (t), and patient's dry weight (V). The integrated graphics for control and diagnostics for the patient's dialysis are displayed on one or more machine-generated displays.

A non-transitory readable medium comprising computer-executable instructions stored thereon is disclosed. The computer-executable instructions instruct one or more processors to display a graphic object representing urea performance based on at least one measurement from the patient's Dialysis performance, said graphic object including at least a first, second, and third parameter; display at least one dynamic graphical line from the first parameter being displayed to the second parameter being displayed, and wherein the displaying of the dynamic graphical line comprises illustrating at least one functional relationship between the first and second parameters; and display a Fractional Urea Clearance (Kt/V) graphic object representing the patient's dialysis urea reduction performance, wherein displaying the Kt/V graphic object comprises displaying the Dialyzer Clearance (K), dialysis treatment duration (t), and patient's dry weight (V).

A method for displaying integrated graphics for control and diagnostics for a patient's dialysis is disclosed. The method comprising displaying a graphic object representing urea performance based on at least one measurement from the patient's Dialysis performance, said graphic object including at least a first, second, and third parameter; displaying at least one dynamic graphical line from the first parameter being displayed to the second parameter being displayed, and wherein the displaying of the dynamic graphical line comprises illustrating at least one functional relationship between the first and second parameters; and displaying a Urea Reduction Rate (QUR) graphic object representing the patient's dialysis urea reduction performance, wherein displaying the Urea Reduction Rate (QUR) graphic object comprises displaying arterial blood urea flow rate (QUB_(A)), venous blood urea flow rate QUB_(V), Total Urea Reduction (TUR), and the dialysis treatment duration (t). The integrated graphics for control and diagnostics for the patient's dialysis are displayed on one or more machine-generated displays.

A non-transitory readable medium comprising computer-executable instructions stored thereon is also disclosed. The computer-executable instructions instruct one or more processors to display a graphic object representing urea performance based on at least one measurement from the patient's Dialysis performance, said graphic object including at least a first, second, and third parameter; display at least one dynamic graphical line from the first parameter being displayed to the second parameter being displayed, and wherein the displaying of the dynamic graphical line comprises illustrating at least one functional relationship between the first and second parameters; and display a Urea Reduction Rate (QUR) graphic object representing the patient's dialysis urea reduction performance, wherein displaying the Urea Reduction Rate (QUR) graphic object comprises displaying arterial blood urea flow rate (QUB_(A)), venous blood urea flow rate QUB_(V), Total Urea Reduction (TUR), and the dialysis treatment duration (t).

Disclosed is also a dialysis system with one or more algorithms that identifies root causes of failures or suboptimal conditions and related parameters of the dialysis system and the parameters affected by such failures and highlights such parameters using at least one of color, alarms, and text. The dialysis system comprises a computing device comprising one or more processors, one or more memory devices coupled to the one or more processors, and a machine-generated display, wherein the one or more processors are programmed to execute instructions corresponding to the one or more algorithms stored in the one or more memory devices to identify root causes of failures or suboptimal conditions and related parameters of the dialysis system and the parameters affected by such failures and highlight such parameters using at least one of color, alarms, and text displayed on the machine-generated display.

Disclosed also is a dialysis system with one or more algorithms that provides recommendations for corrective actions to correct failures root causes and restore the functions of the dialysis system. The dialysis system comprises a computing device comprising one or more processors, one or more memory devices coupled to the one or more processors, and a machine-generated display, wherein the one or more processors are programmed to execute instructions corresponding to the one or more algorithms stored in the one or more memory devices to provide recommendations for corrective actions to correct failures root causes and restore the functions of the dialysis system and display such recommendations on the machine-generated display.

Disclosed is also a dialysis system with one or more algorithms that identifies parameters related to root causes of failures or suboptimal conditions of the dialysis system, and the parameters affected by such failures, and automatically controls system functions comprising at least one of arterial blood flow setting, dialysate flow, and dialysis treatment duration to restore normal functions of the dialysis system. The dialysis system comprises a computing device comprising one or more processors, one or more memory devices coupled to the one or more processors, and a machine-generated display, wherein the one or more processors are programmed to execute instructions corresponding to the one or more algorithms stored in the one or more memory devices to identify parameters related to root causes of failures or suboptimal conditions of the dialysis system and display such parameters on the machine-generated display.

A method for managing the physiological state of a patient is also disclosed. The method comprises communicating an animated balance object to a user, wherein the balance object is representative of physiological data from the patient's cardiovascular system; and controlling delivery of a medication to the patient based on the physiological data. The animated balance object is communicated to the user by being displayed on one or more machine-generated displays.

BRIEF DESCRIPTION OF THE DRAWINGS

FIGS. 1a and 1b are schematic figures of variations of the patient management system.

FIG. 2a illustrates a variation of the displays and controls of the patient management system during physiological inspiration.

FIG. 2b illustrates the variation of the displays and controls of FIG. 2a during physiological expiration.

FIG. 2c illustrates the variation of the displays and controls of FIG. 2a during decrease in systemic vascular resistance resulting in increase in systemic vascular blood flow rate.

FIG. 2d illustrates the variation of the displays and controls of FIG. 2a during an increase in heart rate resulting in increase in pulmonary and systemic cardiac output.

FIG. 3a illustrates a variation of the cardiac displays and controls of the patient management system.

FIG. 3b illustrates a variation of the heart rate and stroke volume displays and controls of the patient management system.

FIG. 3c illustrates a variation the cardiac contractility and pre-load displays and controls of the patient management system.

FIG. 4a illustrates a variation of the systemic vascular displays and controls of the patient management system.

FIG. 4b illustrates a variation of the systemic vascular oxygenation display of the patient management system.

FIG. 4c illustrates a variation of the systemic vascular hemodynamics displays and controls of the patient management system.

FIG. 4d illustrates a variation of the systemic vascular carbon dioxide removal displays and controls of the patient management system.

FIG. 5a illustrates a variation of the pulmonary vascular displays and controls of the patient management system.

FIG. 5b illustrates a variation of the pulmonary vascular oxygenation displays and controls of the patient management system.

FIG. 5c illustrates a variation of the pulmonary vascular hemodynamics displays and controls of the patient management system.

FIG. 5d illustrates a variation of the pulmonary vascular carbon dioxide removal displays and controls of the patient management system.

FIG. 6 illustrates a variation of the expanded medications display and controls of the patient management system.

FIG. 7 illustrates a variation of the fluids management display and controls of the patient management system.

FIG. 8a illustrates a variation of the hemodynamics, oxygen delivery-consumption, and carbon dioxide production-removal balance object displays of the patient management system.

FIG. 8b illustrates a variation of the hemodynamics balance object display of the patient management system.

FIG. 8c illustrates a variation of the oxygen delivery-consumption balance object display of the patient management system.

FIG. 8d illustrates a variation of the carbon dioxide production-removal balance object display of the patient management system.

FIG. 9 illustrates a variation of a dialysis management system.

FIG. 10 illustrates a variation of a management system display on a variation of a visual display monitor.

FIG. 11 illustrates a variation of a dialysis system anatomical display.

FIG. 12 illustrates a variation of an Urea Reduction Rate display.

FIG. 13 illustrates a variation of an Urea Concentration display.

FIG. 14 illustrates a variation of an Urea Reduction Ratio display.

FIG. 15 illustrates a variation of a Fractional Urea Clearance display.

FIG. 16 illustrates a variation of a Dialyzer Clearance display.

FIG. 17 illustrates a variation of an Urea Reduction Ratio and Fractional Urea Clearance balance object display.

DETAILED DESCRIPTION

A patient management system 150 is described. The patient management system 150 can monitor, control and communicate (e.g., visually display or audibly sound) patient physiological diagnosis, status and treatment. The system can have a human-machine interface for process monitoring and control of patient's cardiovascular and ventilation systems, and for the administration and management of patient's medications and fluids capable of the creation of displays and controls, wherein such displays are collections of one or more displays that may be graphs showing mathematical relationships or graphical in nature, and wherein such controls are collections of one or more controls that may be used to control patient's cardiovascular and ventilation systems, and for the administration and management of patient's medications and fluids using a touch screen, a mouse, keyboard, or any other human-machine interface control.

System Components

FIG. 1a illustrates that the management system 150 can have one or more direct subsystems 100, such as a monitoring system 1, a medication delivery system 2, an IV fluids delivery system 3, a bleeding system 4, a urine output system 5, or combinations thereof. The management system 150 can be for cardiovascular and respiratory management and administration and management of patient's medications and fluids. Any or all of the direct subsystems can be directly attached to the patient 30, for example by one or more probes 10. Any or all of the direct subsystems can be controlled by a micro-processor executing a management algorithm 6.

The management algorithm 6 can monitor and identify parameters transitioning from normal conditions or settings to abnormal conditions or settings and the possible consequences on system functions or goals including failures as a result of such parameters' transitions. The algorithm 6 can highlight the abnormal parameters settings and system functions or goals that can be affected as a result of such parameters' transitions using color or visual or auditory alarms in order to make such parameters and system conditions more prominent and visible.

When system failures or abnormal system functions or conditions occur or when parameters transition from normal conditions or settings to abnormal conditions or settings, the management algorithm 6 can identify root causes and parameters related to the failures or abnormal system functions or conditions or parameters transition from normal conditions or settings to abnormal conditions or settings. The management algorithm 6 can highlight the abnormal parameters settings, parameters or functions related to failures root causes, and affected system functions or goals that were or could be impacted using color or visual or auditory alarms in order to make such parameters and system conditions more prominent and visible. When system parameters transition from normal conditions or settings to abnormal conditions or settings or when system failures or abnormal functions or conditions occur, the management algorithm 6 can provide suggested actions to the user to prevent or correct abnormal system functions or failures and restore normal system functions.

When system parameters transition from normal conditions or settings to abnormal conditions or settings or when system failures or abnormal functions or conditions occur, the management algorithm 6 can automatically adjust parameters to prevent or correct abnormal system functions or failures and restore normal system functions.

The management algorithm 6 can display information through a one-way or two-way (e.g., touch screen) visual display monitor 7 and/or speakers (e.g., output speakers and/or one or more microphones). The management algorithm 6 can receive instructions from a control 8 which can be a separate input device (e.g., a keyboard, mouse or joystick), an integrated input device (e.g., the touch screen on the display monitor 7), or combinations thereof. The user 20 can provide instructions to the management algorithm 6 through the control 8, which can be part of the display 7.

The direct subsystems 100 can be physically integrated with the management algorithm 6, the control 8, the display 7 or combinations thereof. For example, the direct subsystems, and the management algorithm 6, the control 8, the display 7 or combinations thereof can be in a unitary form factor, such as in a single case or container.

FIG. 1b illustrates that the management system 150 can be physically distinct and separate from the direct subsystems 100. The management system 150 can be in data communication with the direct subsystems 100 through local (e.g., wired) or remote (e.g., wireless) communication. The direct subsystems 100 can be separate physical components that can be releasably connectable to the management system 150 through wired or wireless communication. The direct subsystems 100 can provide data to and/or receive data from the management algorithm 6.

Displays

FIG. 2a illustrates that the management system 150 can display a management display 200 on the visual display monitor 7. The management display 200 can have a cardiac display 300 that can include a left heart display and a right heart display, a systemic vascular display 400, a pulmonary display 500 that can include a pulmonary vascular display and a ventilation display, a medication administration display 600, a fluid display 700, a blood flow, oxygenation, and carbon dioxide balance object display 800, or combinations and/or pluralities thereof. The management display 200 can have graphical objects representative of the vascular system connecting the cardiac display 300 to the pulmonary display 500 and/or the systemic vascular display 400 to the cardiac display 300.

The management display 200 can have text labels on the display, for example, the type, quantity and timing of the medications can be shown on the medication administration display 600, and the systemic blood gas measurements can be shown in the graphic object representations of the vascular system.

The management display 200 can be animated to show different states in real-time. For example, the animation can include graphic object changes showing increased lung size in the pulmonary display 500 to indicate inspiration, beating of the heart in the cardiac display 300 to indicate cardiac function, expansion and contraction of the capillaries or vessels in the systemic vascular display 400 to represent vascular dilation, or combinations thereof. The graphic objects indicating medication and fluid levels, the vascular system flow and all other data can also animate during use.

FIG. 2a illustrates that the management display 200 can be in a first configuration. FIG. 2b illustrates that the management display 200 can be animated to have a second configuration. FIG. 2c illustrates that the management display 200 can be animated to have a third configuration. For example, the systemic vascular display 400 can show increased vascular dilation. The balance control display 800 can alter in shape, reflecting a chance of its components. FIG. 2d illustrates that the fluid delivery settings and levels have changed, the Heart Rate has increased resulting in increased Left Heart and Right Heart cardiac output. The result of increasing Left Heart and Right Heart cardiac output is shown on the cardiac function balance object display 899.

Left Heart Displays

FIG. 3a illustrates that the cardiac display 300 can have a heart rate and stroke volume display 399 and a contractility and pre-load display 398. The cardiac display 300 shows a graphical representation of the higher-level goals, the middle-level functional parameters, and the lower-level functional parameters and controls used in monitoring and managing the heart including cardiac output, stroke volume, heart rate, contractility, and pre-load. The graphical representation shows interrelationships and interactions between the higher-level goals, the functional parameters, and the lower-level functional parameters and controls used in monitoring and managing the heart including its cardiac output, stroke volume, heart rate, contractility, and pre-load.

The cardiac display 300 can include a left heart display showing a graphical representation of the higher-level goals, the middle-level functional parameters, and the lower-level functional parameters and controls used in monitoring and managing the left heart including its cardiac output, stroke volume, heart rate, contractility, and pre-load. The graphical representation also shows interrelationships and interactions between the higher-level goals, the functional parameters, and the lower-level functional parameters and controls used in monitoring and managing the left heart including its cardiac output, stroke volume, heart rate, contractility, and pre-load.

Left Heart Cardiac Output, Stroke Volume, and Heart Rate Display

FIG. 3b illustrates that the heart rate and stroke volume display 399 can show a left heart display showing the higher level goal of Left Heart Cardiac Output (LHCO) 305. The LHCO 305 can be projected (i.e., copied) onto the balance display as LHCO 801. The LHCO 305 can be visually linked by lines on the display to the LHCO 801 and/or 305.

The functional variables can include Heart Rate (HR), graphed along axis 303, and Left Heart Stroke Volume (LHSV), graphed along axis 302. The variables in the Left Heart Display can be shown and integrated in a graph where the HR value is shown on one axis 303, and the LHSV value is shown on another axis 302 perpendicular to the HR axis. The area of the rectangle along the HR and LHSV values is a measure of the Left Heart Cardiac Output (LHCO) value (HR×LHSV). The LHSV can be projected onto the contractility and pre-load display 398 as LHSV 310. The LHSV represented in the cardiac output display 399 can be visually linked by lines on the display to the LHSV 310 on the contractility and pre-load display 398.

An administered medication label 311 and the medication concentration or dose 312 can be shown adjacent to a target or control graph of the medication with a setting level 313. The setting level 313 can be adjusted by the user and/or the management algorithm. Relationships between administered medications and fluids and the functional variables HR and LHSV can be shown by a line 314 connecting between the flow rate or dose of the administered medication or fluid and the HR or LHSV functional parameter or a combination thereof which the medication or fluid has an effect on. The display 399 presents such information onto a graphical representation showing the anatomy of the left heart (e.g., behind the opaque graphs, as shown, or layered with translucent or transparent graphs). The anatomical graphical representation can show the left atrium and ventricle, the aorta, and pulmonary vein.

Right Heart Displays

The cardiac display 300 can include a right heart display showing a graphical representation of the higher-level goals, the middle-level functional parameters, and the lower-level functional parameters and controls used in monitoring and managing the right heart including its cardiac output, stroke volume, heart rate, contractility, and pre-load. The display also shows interrelationships and interactions between the higher-level goals, the middle-level functional parameters, and the lower-level functional parameters and controls used in monitoring and managing the right heart including its cardiac output, stroke volume, heart rate, contractility, and pre-load.

Right Heart Cardiac Output, Stroke Volume, and Heart Rate Display

FIG. 3b illustrates that the heart rate and stroke volume display 399 can show the higher level goal represented is Right Heart Cardiac Output (RHCO) 304. The RHCO 304 can be projected onto the balance display as RHCO 802 and/or on the contractility and pre-load display 398 as RHCO 304. The RHCO 304 can be visually linked by lines on the display to the RHCO 802.

The functional parameters include Heart Rate (HR), graphed along axis 303, and Right Heart Stroke Volume (RHSV), graphed along axis 301. The higher-level goal and functional parameters in the Right Heart Display are shown and integrated in a graph where the HR value is shown on one axis 303, and the RHSV value is shown on another axis 301 perpendicular to the HR axis. The RHSV can be projected onto the contractility and pre-load display 398 as RHSV 309. The RHSV represented in the cardiac output display 399 can be visually linked by lines on the display to the RHSV 309 on the contractility and pre-load display 398.

The area of the rectangle along the HR and RHSV values is a measure of the Right Heart Cardiac Output value. A measurement of the RHCO 304 is shown on the display. Relationships between administered medications and fluids and the functional parameters HR and RHSV are shown by a line connecting between the flow rate or dose of the administered medication or fluid and the HR or RHSV functional parameter or a combination thereof which the medication or fluid has an effect on. The display presents such information onto a graphical representation of the anatomy of the right heart. The anatomical graphical representation shows the right atrium and ventricle, the pulmonary artery, the superior vena cava, and inferior vena cava.

Left Heart Pre-Load & Contractility Display

FIG. 3c illustrates that the contractility and pre-load display 398 can have the higher level goal of displaying Left Heart Stroke Volume (LHSV) 310 represented in the cardiac output display 399. The functional variables include pre-load (PL), shown on axis 308, and left heart contractility (CON) 307. The higher-level goal and functional parameters in the display are integrated in a graph where the PL value is shown on one axis 308, and the CON value is shown another axis 307 perpendicular to the PL axis 308. The area of the rectangle along the PL and CON values is a measure of the LHSV 310. A measurement of the LHSV is shown on the Pre-Load and Contractility display 398. A line can connect between the LHSV 310 on the pre-load and contractility display 398 and the LHSV 302 on the cardiac output display 399. Relationships between administered medications and fluids and the functional variables PL and CON are shown by a line connecting between the flow rate or dose of the administered medication or fluid display 700 and the PL or CON functional parameter or a combination thereof which the medication or fluid has an affect on.

Right Heart Pre-Load & Contractility Display

FIG. 3c illustrates that the contractility and pre-load display 398 can have a higher level goal of displaying right heart stroke volume (RHSV) 309 represented in the cardiac output display 399. The functional parameters include Pre-Load (PL), shown on axis 308 and right heart contractility (CON), shown on axis 306. The higher-level goal and functional parameters in the display are integrated in a graph where the PL value is shown on one axis 308, and the CON value is another axis 306 perpendicular to the PL axis. The area of the rectangle along the PL and CON values is a measure of the RHSV. A measurement of the RHSV is shown on the pre-load and contractility display 398, and a line can connect between the RHSV 309 on the pre-load and contractility display 398 and the RHSV 301 on the cardiac output display 399. Relationships between administered medications and fluids and the functional parameters PL and CON are shown by a line connecting between the flow rate or dose of the administered medication or fluid and the PL or CON functional parameter or a combination thereof which the medication or fluid has an effect on.

Cardiovascular System Displays Systemic Vascular Display

FIG. 4a illustrates that the systemic vascular display 400 can have a systemic vascular blood flow display 498, a systemic oxygenation display 497, a carbon dioxide (CO₂) removal display 499, and combinations thereof. The vascular blood flow display 498 can animate to display the increase in diameter of the vessels during decreased vascular resistance.

The systemic vascular display 400 shows a representation of the higher-level goals, the middle-level functional parameters, and the lower-level functional parameters and controls used in monitoring and managing the systemic vascular system including the systemic arterial and venous vascular blood flow, systemic arterial and venous vascular blood pressures, and systemic vascular resistance. The Systemic Vascular Display's graphical representation also shows interactions between the higher-level goals, the middle-level functional parameters, and the lower-level functional parameters and controls used in monitoring and managing the systemic vascular circulatory system including the systemic arterial and venous vascular blood flow, systemic arterial and venous vascular blood pressures, and systemic vascular resistance. The display presents such information onto a graphical representation of the anatomy of the systemic vascular system. The anatomical graphical representation shows the systemic arterial and venous vascular systems.

FIG. 4c illustrates that in the systemic vascular blood flow display 498 the higher level goal represented is systemic blood flow (SBF) 404. The middle-level functional parameters can include Systemic Arterial Pressure (SAP), shown along axis 403, and Systemic Venous Pressure (CVP), shown along axis 402, and the lower-level functional parameters can include the Systemic Vascular Resistance (SVR), shown along axis 419. The higher-level goal and functional parameters in the systemic vascular blood flow display 498 can be shown and integrated in a graph where SAP and CVP values are shown on one axis, and the SVR value is on another axis perpendicular to the SAP and CVP axis. A line connecting between the SAP and CVP values along the SVR axis indicates the systemic blood flow (SBF) 404 value by its slope.

Administered medications can be shown in the systemic vascular blood flow display 498, for example listing the medication name 415 and/or the medication concentration and/or dose 416. Relationships between administered medications and fluids and the functional parameters SAP, CVP, and SVR can be shown by a line 401 connecting between the flow rate or dose of the administered medication or fluid and the functional parameter SAP, CVP, or SVR or a combination thereof which the medication or fluid has an effect on. The graphical object representing the medication can be shown along a dosage axis 418 and can have a target or current dosage rate 417 shown.

The SBF 404 can be projected onto the balance object display 800 as SBF 803. SBF 404 can be linked by a line to SBF 803.

Systemic Oxygen Display

FIG. 4b illustrates that the systemic vascular display 400 can have a systemic oxygenation display 497. The Systemic Arterial Oxygen Content (SAO₂C), shown on axis 406, and the Systemic Blood Flow Rate (SBF) 407 can be used to calculate the Systemic Arterial Oxygen Flow Rate (SAO₂FR) 409. The Systemic Venous Oxygen Content (SVO₂C), shown on axis 405, and the Systemic Blood Flow Rate (SBF) 407 can be used to calculate the Systemic Venous Oxygen Flow Rate (SVO₂FR) 408. An object display is used to show the difference between SAO₂FR 409 and SVO₂FR 407, indicating oxygen consumption 421.

The oxygen consumption 421 can be projected onto the balance object display 898 as oxygen consumption 805. The oxygen consumption 421 can be linked by a line to the oxygen consumption 805.

Systemic Carbon Dioxide Display

FIG. 4d illustrates that the systemic vascular display 400 can have a systemic carbon dioxide (CO₂) display 499. The systemic CO₂ display 499 can show that the Systemic Arterial CO₂ Content (SACO₂C), shown on axis 411, and the Systemic Blood Flow Rate (SBF) 412 can be used to calculate the Systemic Arterial CO₂ Flow Rate (SACO₂FR) 414. The Systemic Venous CO₂ Content (SVCO₂C), shown on axis 410, and the Systemic Blood Flow Rate (SBF) 412 can be used to calculate the Systemic Venous CO₂ Flow Rate (SVCO₂FR) 413. An object display can be used to show the difference between SACO₂FR 414 and SVCO₂FR 413, indicating CO₂ production 420. The CO₂ production 420 can be projected onto the balance object display 897 as CO₂ production 806. The CO₂ production 420 can be linked by a line to CO₂ production 806.

Pulmonary Vascular Display

FIG. 5a illustrates that the pulmonary display 500 can have a pulmonary vascular display 598 and one or more ventilation displays, such as a pulmonary oxygenation display 597 and a pulmonary carbon dioxide display 599.

FIG. 5c illustrates that the pulmonary vascular display 598 shows a representation of the higher-level goals, the middle-level functional parameters, and the lower-level functional parameters and controls used in monitoring and managing the pulmonary vascular system including the pulmonary arterial and venous vascular blood flow, pulmonary arterial and venous vascular blood pressures, and pulmonary vascular resistance. The Pulmonary Vascular Display's graphical representation also shows interactions between the higher-level goals, the middle-level functional parameters, and the lower-level functional parameters and controls used in monitoring and managing the pulmonary vascular system including the pulmonary arterial and venous vascular blood flow, pulmonary arterial and venous vascular blood pressures, and pulmonary vascular resistance. The display presents such information onto a graphical representation of the anatomy of the pulmonary vascular system. The anatomical graphical representation shows representations of the lungs and the pulmonary arterial and venous vascular systems.

The Pulmonary Vascular Display 598 displays the higher level goal of Pulmonary Blood Flow (PBF) 504, the middle-level functional parameters include Pulmonary Arterial Pressure (PAP), shown on axis 502, and Pulmonary Venous Pressure (PcW), shown on axis 503. The lower-level functional parameters include the Pulmonary Vascular Resistance (PVR), shown on axis 532. The higher-level goal and functional parameters in the Pulmonary Vascular Display 598 can be shown and integrated in a graph where PAP and PcW values are shown on one axis, 502 and/or 503, and the PVR value is on another axis 532 perpendicular to the PAP and PcW axis. A line connecting between the PAP and PcW values along the PVR axis 532 indicates the Pulmonary Blood Flow (BPF) 504 by the slope of that line.

The PBF 504 can be projected onto the balance object display 800 as PBF 804. A line can link PBF 504 to PBF 804.

Administered medications can have labels 528 and/or medication concentration and/or dose levels 529 shown. Relationships between administered medications and fluids and the functional parameters PAP, PcW, and PVR are shown by a line 501 connecting between the flow rate or dose of the administered medication or fluid and the functional parameter PAP, PcW, or PVR or a combination thereof which the medication or fluid has an affect on.

The graphical object representing the medication can be shown along a dosage axis 531 and can have a target or current dosage rate 530 shown.

Lungs and Ventilation Display

The Pulmonary Vascular display 598 can have an anatomical graphical representation of the lungs. The lungs graphical representation can include a Respiratory Rate (RR) 507 on a RR graph 508, Tidal Volume (TV), Alveolar Oxygen Concentration (F_(alv)O₂), Inspired Oxygen Concentration (F_(i)O₂), Alveolar CO₂ Concentration (F_(alv)CO₂), Expired CO₂ Concentration (F_(exp)CO₂) 516, Minute Ventilation (MV) 515, a ratio of partial pressure of alveolar oxygen to alveolar carbon dioxide (P_(alv)O₂/P_(alv)CO₂) 517, or combinations thereof.

Information pertaining to mechanical ventilation can be presented on or around the anatomical lungs graphical representation, for example if the patient is being ventilated mechanically. The display can include ventilation information displays including Respiratory Rate (RR), Tidal Volume (TV), Inspired Oxygen Concentration (F_(i)O₂), Inspiratory Flow Rate, Inspiratory Time, Inspiratory/Expiratory Time Ratio (I:E ratio) 509 on an I:E graph 510, Positive Inspiratory Pressure (PIP) 506 or combinations thereof.

Mapped onto each of the mechanical ventilation variables Respiratory Rate (RR), Tidal Volume (TV) 511 on a TV graph 512, Inspired Oxygen Concentration (F_(i)O₂) 513 on an F_(i)O₂ graph 514, Inspiratory Flow Rate, Inspiratory Time, and Inspiratory/Expiratory Time Ratio (I:E ratio) can be a control for controlling each of the variables. The user can control patient's mechanical ventilation by manipulating controls of the mechanical ventilation variables on the Lungs and Ventilation display including Respiratory Rate (RR), Tidal Volume (TV), Inspired Oxygen Concentration (F_(i)O₂), Inspiratory Flow Rate, Inspiratory Time, Inspiratory/Expiratory Time Ratio (I:E ratio).

Pulmonary Oxygenation Display

FIG. 5b illustrates that the Pulmonary Oxygenation display 597 can have a Pulmonary Arterial Oxygen Content (PAO₂C), shown along the axis 518, and the Pulmonary Blood Flow Rate (PBF) 520 can be used to calculate the Pulmonary Arterial Oxygen Flow Rate (PAO₂FR) 521, while the Pulmonary Venous Oxygen Content (PVO₂C), shown on the axis 519, and the Pulmonary Blood Flow Rate (PBF) 520 can be used to calculate the Pulmonary Venous Oxygen Flow Rate (PVO₂FR) 522. An object display shows the difference between PAO₂FR 521 and PVO₂FR 522, indicating an oxygen transfer rate from the lungs to the blood (Blood Oxygenation 533).

The blood oxygenation 533 can be projected onto the balance object 898. A line can link the blood oxygenation 533 to the blood oxygenation 807.

Ventilation properties can be shown in the graphic objects of the organs themselves, such as on the graphic objects of the vascular system between the organs. On the graphic objects for the vessels within the cardiovascular representation, the systemic arterial oxygen saturation (SaO2SAT), systemic venous oxygen saturation (SvO2SAT), systemic arterial and venous oxygen pressures PaO₂, PvO₂, pulmonary arterial and venous oxygen pressures PaO₂, PvO₂, and combinations thereof can be shown.

Pulmonary CO₂ Display

In the Pulmonary CO₂ display 599, the Pulmonary Arterial CO₂ Content (PACO₂C), shown on axis 523, and the Pulmonary Blood Flow Rate (PBF) 525 can be used to calculate the Pulmonary Arterial CO₂ Flow Rate (PACO₂FR) 526, while the Pulmonary Venous CO₂ Content (PVCO₂C), shown along axis 524, and the Pulmonary Blood Flow Rate (PBF) 525 can be used to calculate the Pulmonary Venous CO₂ Flow Rate (PVCO₂FR) 527. An object display shows the difference between PACO₂FR 526 and PVCO₂FR 527, indicating a CO₂ mass transfer rate 534 from the blood to the lungs (CO₂ Elimination from the blood).

The CO₂ mass transfer rate 534 can be projected onto the balance object 897. A line can link the CO₂ mass transfer rate 534 to the CO₂ mass transfer rate 808.

In the vessels within cardiovascular representation, displayed are the systemic arterial CO₂ pressure PaCO₂, systemic venous CO₂ pressure PvCO₂, and pulmonary arterial and venous CO₂ pressures PaCO₂, PvCO₂, respectively.

Ventilation properties can be shown in the graphic objects of the organs themselves, such as on the graphic objects of the vascular system between the organs.

Medication Administration and Management Display

FIG. 6 illustrates that the Medication Administration and Management Display 600 can display that each medication administered to the patient can be observed, controlled and managed. A display of each administered medication's flow rate and/or dose is shown. The user can select whether to display the medication's flow rate, dose 604 information or a combination thereof. The user can select what time of day to administer the medication, as shown by the horizontal axis 610 labeled with times. Mapped onto the medication flow rate 604 information is the medication's flow rate control or regulator 603 (e.g., can be shown as an arrow on the touch screen display 7). The user can manipulate the medication's flow rate control (regulator) 603 to adjust the medication's flow rate (i.e., increase or decrease the flow rate setting). Mapped onto the medication dose information 604 is the medication's dose control or regulator 603. The user can manipulate the medication's dose control (regulator) 603 to adjust the medication's dose (i.e., increase or decrease the dose setting).

A line can connect between each medication's flow rate or dose control (regulator) 603 and the cardiovascular functional parameter which the medication has an effect on. For example, vasoconstrictive medications can have a line connecting between the medication's flow rate or dose control (regulator) 603 and the systemic vascular resistance (SVR) 401 or pulmonary vascular resistance (PVR) 501 on the cardiovascular display or a combination thereof. Medications which affect the heart rate 303 can have a line connecting between the medication's flow rate or dose control (regulator) 603 and the heart rate 303 value on the cardiovascular display.

Expanded Medication Administration and Management Display

For each administered medication, the user can select to expand or collapse the medication's administration and management display 600. In the expanded Medication Administration and Management Display 600, the medication's flow rate and/or dose values 604 a,b can be displayed on one axis, while time 610 is shown on another perpendicular axis. The user can choose to display the medication's flow rate or dose or both. The area under the flow rate or dose 604 a,b vs. time 610 graph represents the medication's volume or amount (mass) 605 a,b, respectively. Mapped onto the medication flow rate or dose information 604 a,b is the medication's flow rate or dose control or regulator 603 a,b, respectively. The user can manipulate the medication's flow rate or dose control (regulator) to adjust the medication's flow rate or dose, respectively (i.e., increase or decrease the flow rate or dose setting, respectively). A line connects between each medication's flow rate or dose control (regulator) 603 a,b and the cardiovascular functional parameter which the medication has an affect on.

In combination with the medication flow rate and/or dose and time information, the flow rate/dose vs time display shows the medication's name 601 a,b, concentration 602 a,b, volume and/or amount to be infused to the patient 607 a,b, volume and/or amount administered to the patient 611 a,b, period of medication administration 606 a,b, remaining volume and/or amount to be infused or administered to the patient 608 a,b, remaining time to complete medication administration at the currently set flow rate or dose 609 a,b, and the total volume and/or amount of medication remaining in the reservoir 608 a,b.

Target-Controlled (Model-Driven) Infusion Pump Display

A medication management display 600 can be used for medications infused by target-controlled or model-driven “smart” infusion pumps. The medication management display 600 can have a display showing the medication's flow rate or dose information 604 a,b, as well as the medication's name 601 a,b, concentration 602 a,b, total volume and/or amount, volume and/or amount administered to the patient 611 a,b, period of medication administration, remaining volume (i.e., volume to be infused “VTBI”) 607 a,b, (volume infused “VI”) 605 a,b, (total volume infused) TVI 611 a,b. and/or amount to be infused or administered to the patient, remaining time to complete medication administration at the currently set flow rate or dose (“TR”) 609 a,b, and the total volume and/or amount of medication remaining in the reservoir (“VR”) 608 a,b. Mapped onto the medication flow rate or dose information is the medication's flow rate or dose control or regulator 603, respectively. The user can manipulate the medication's flow rate or dose control (regulator) to adjust the medication's flow rate or dose (as shown by target dose controls 604 a,b), respectively (i.e., increase or decrease the flow rate or dose setting, respectively).

For each cardiovascular functional parameter 303 which is affected and controlled by a medication being administered using a target-controlled or model-driven infusion pump, a control or regulator 314 of the cardiovascular functional parameter is mapped onto its measurement value on the cardiovascular display. The cardiovascular display then shows both the measured 303 and target (set/desired) 314 values of the cardiovascular functional parameter.

The user can adjust the cardiovascular functional parameter's target, set or desired value 314 by manipulating the medication delivery control 313 on the target control pump anywhere in the management display (e.g., within the cardiovascular display, pulmonary display, systemic vascular display) which in turn will automatically control and adjust the flow rate or dose of the medication or medications which affect this (e.g., cardiovascular, pulmonary, systemic vascular) functional parameter.

The functional parameter can be adjusted to control the infusion pump. For example, a target functional parameter can be entered through the control 8. The target functional parameter can be processed by the management algorithm 6, which in turn can automatically control and adjust the flow rate or dose of the medication or medications which affect this (e.g., cardiovascular, pulmonary, systemic vascular) functional parameter. For example, a smart infusion pump can be used to control delivery of the medication to the patient.

As an example, a line connects between the cardiovascular functional parameter's control or regulator on the cardiovascular display and the flow rate or dose information on the medication display of the medication or medications which affect the cardiovascular functional parameter. The target-controlled or model-driven infusion pump system monitors the cardiovascular functional parameter's measured value and adjusts the medication's flow rate or dose automatically to achieve the set or desired cardiovascular functional parameter value. For example, when the user adjusts the target or desired heart rate value 314 on the cardiovascular display, the pump adjusts the flow rate or dose of the medication or medications which control the heart rate accordingly to achieve the desired heart rate value. The pump system monitors the heart rate value and adjusts the medication's flow rate automatically to achieve the desired heart rate value. Similarly, when the user adjusts the left heart stroke volume (LHSV) or contractility values on the cardiovascular display, the pump adjusts the flow rate or dose of the medication or medications which affect LHSV or contractility, respectively.

Medication Administration and Management Graphical Display & Animation

Each medication being administered to the patient is represented graphically by displaying an image of the medication's reservoir such as an image of a medication bag, bottle, or syringe. On the image representing the medication displayed is the medication's name, concentration, total volume and/or amount, administration flow rate and/or dose, period of medication administration, remaining volume and/or amount to be infused or administered to the patient, remaining time to complete medication administration at the currently set flow rate or dose, and the total volume and/or amount remaining in the reservoir.

A line representing the administered medication's flow in a clear plastic tubing routes from the medication's reservoir to its administered location on the patient's vascular system's anatomical graphical representation within the cardiovascular display. This line has a similar color to the medication's color (e.g., gray for a clear color medication) and connects between each administered medication reservoir and its administration location on the patient's vascular system's anatomical graphical representation within the cardiovascular display. The medication line can be animated to show the medication flowing in a plastic tubing from its reservoir bag to its administered location on the patient's vascular system's anatomical graphical representation within the cardiovascular display. Higher medication flow rate is represented by a medication line moving at a faster rate.

A display of the medication's flow rate and/or dose is shown on the medication's reservoir and/or anywhere on the medication line connecting between the medication's reservoir and its administration location on the patient's vascular system's anatomical graphical representation within the cardiovascular display.

Patient's Fluids Administration and Management Display

FIG. 7 illustrates that the fluid management display 700 can display, control, and manage any or all fluids administered to the patient including IV solutions, blood, etc. Also, all fluids collected from the patient such as urine and blood loss are all displayed and managed in this display. For each administered fluid, displayed are the fluid's name 701 a,b, administration flow rate 704 a,b, volume infused 702 a,b, volume to be infused 703 a,b, time remaining to complete fluid administration at the currently set rate, and volume remaining in the fluid reservoir (bag, syringe, bottle, etc.). Mapped onto the fluid administration flow rate 704 a,b is the fluid's flow rate control or regulator 713 a,b. The user can control and adjust the fluid's flow rate by manipulating its flow control or regulator to increase or decrease the fluid flow rate value. In this flow rate control, the user can move the flow rate value indicator from the current flow rate value to the desired flow rate value. When several fluids are being administered to the patient, a Total Inflow Rate (TIFR) 705 is calculated and displayed by the system.

In the Fluids Administration and Management Display 700 all fluids collected from the patient are displayed and managed such as urine collected from the patient and blood loss, etc. For each fluid being collected from the patient, displayed are the fluid's name, collection flow rate 706, 707, and volume collected 709, 710. When several fluids are being collected from the patient, a Total Outflow Rate (TOFR) 708 can be calculated and displayed by the system.

Inflow and Outflow Fluids Balance Display

The Inflow and Outflow Fluids Balance display 712 shows balance information between fluids being administered to the patient (inflow fluids) and fluids being collected from the patient (outflow fluids) using one or multiple object displays. Each fluid balance object display shows balance information both graphically and numerically by displaying information such as difference or % difference between inflow and outflow rate values for inflow and outflow fluids, and difference or % difference between inflow and outflow volumes (e.g., volume administered to patient and volume collected from patient) for inflow and outflow fluids.

The user can select which inflow and outflow fluids to be incorporated in any fluids balance object display 700. For example, the user could select blood collected from the patient (i.e., blood loss) and blood and IV solutions administered to the patient to be incorporated in a blood fluid balance object display 711. If multiple inflow and/or outflow fluids are incorporated in one fluids balance object display, a second balance object display is displayed showing balance information between TIFR and TOFR values and/or between total administered volume and total collected volume for the inflow and outflow fluids.

Balance Object Display

FIG. 8a illustrates that the balance object display 800 can have a blood flow balance object display 899, an oxygenation balance object display 898 and a carbon dioxide balance object display 897.

The balance object display 800 can have integral or configurate displays. For example, the balance object display can show interactions and balance information among the higher-level goals of managing the cardiovascular, pulmonary and fluid systems.

FIG. 8b illustrates that the blood flow balance object display can display SBF 803, PBF 804, LHCO 801, and RHCO 802 as an object or integral display. The blood flow balance object display can integrate the SBF 803, PBF 804, LHCO 801, and RHCO 802 into one object. In the blood flow balance object display 899, each of the SBF 803, PBF 804, LHCO 801, and RHCO 802 or a function thereof is represented as a part of an object (e.g., a side of a rectangle or triangle). When the different parts are combined together they form a certain shape of a certain object which can be used by the user to quickly deduct the relationships between SBF 803, PBF 804, LHCO 801, and RHCO 802. For example, if each of the SBF 803, PBF 804, LHCO 801, and RHCO 802 is represented as a side of a rectangle object, then the object display formed by the combination of the different parts will be a rectangle. The shape of the rectangle is a graphical representation of the balance between SBF 803, PBF 804, LHCO 801, and RHCO 802. For example, if SBF 803, PBF 804, LHCO 801, and RHCO 802 are all equal, then the object display 899 formed will be a square which can be used by the user to quickly deduct the relationships between SBF 803, PBF 804, LHCO 801, and RHCO 802.

FIG. 8c illustrates that the oxygenation balance object display 898 can have oxygen consumption 805 and blood oxygenation 807. As long as the oxygen consumption 805 and the blood oxygenation 807 remain substantially in balance, the oxygenation balance object display 898 can maintain an expected (e.g., rectangular) configuration. If the oxygen consumption 805 or the blood oxygenation 807 become out of balance, then the configuration of the oxygenation balance object display 898 can alter to become a configuration to denote irregularities (e.g., circular, overly elongated, etc.) to the user.

FIG. 8d illustrates that the carbon dioxide balance object display 897 can have CO₂ production 806 and CO₂ removal 808. As long as the CO₂ production 806 or CO₂ removal 808 remain substantially in balance, the carbon dioxide balance object display 897 can maintain an expected (e.g., rectangular) configuration. If the CO₂ production 806 or CO₂ removal 808 become out of balance, then the configuration of the carbon dioxide balance object display 897 can alter to become a configuration to denote irregularities (e.g., circular, overly elongated, etc.) to the user.

Animations Cardiovascular Display Animation

The cardiovascular graphical representation is also animated showing the heart beating (contracting) at the measured HR value. The LHSV and RHSV measurements can be shown in the animation by the size of expansion of the left and right ventricles, respectively. The blood can also be shown circulating throughout the cardiovascular system including the left and right hearts and systemic and pulmonary vascular systems. The blood in the left heart, the systemic arterial vascular system, and the pulmonary venous vascular system is shown in red color to indicate blood oxygenation. The blood flowing in the right heart, the pulmonary arterial vascular system, and the systemic venous vascular system is shown in blue color to indicate blood de-oxygenation. The intensity of the blood's red and blue colors can indicate the systemic and pulmonary arterial and venous O₂ and CO₂ contents, systemic P_(a)O₂, P_(v)O₂, P_(a)CO₂, and P_(v)CO₂ and pulmonary P_(a)O₂, P_(v)O₂, P_(a)CO₂, and P_(v)CO₂.

Lungs Display Animation

The lungs graphical representation can be animated to show the lungs expand or inflate to mimic inspiration and deflate to mimic expiration. The patient's RR is animated by the rate at which the lungs expand and deflate, while the TV measurement is animated by the size of lungs' expansion. The lungs' color during inspiration (i.e., lungs' expansion) can turn to green to indicate alveolar oxygenation, while lungs' color during expiration (lungs' deflation) can turn to gray to indicate CO₂ transfer to the lungs. The intensity or saturation of the lungs' green color can graphically represent the F_(alv)O₂ or F_(i)O₂ values. The intensity or saturation of the lungs' gray color can graphically represent the F_(alv)CO₂ or F_(exp)CO₂ values. Higher F_(alv)O₂ or F_(i)O₂ values are represented by a more intense or saturated green color, and lower F_(alv)O₂ or F_(i)O₂ values are represented by a less intense or saturated green color. Similarly, higher F_(alv)CO₂ or F_(exp)CO₂ values are represented by a more intense or saturated gray color, and lower F_(alv)CO₂ or F_(exp)CO₂ values are represented by a less intense or saturated gray color.

Fluids Administration and Management Graphical Display and Animation

Each fluid being administered to the patient is represented graphically by displaying an image of the fluid's reservoir such as an image of a blood or IV solution bag. On the image representing the fluid being administered, displayed is the fluid's name, concentration or dose information, total volume, administration flow rate, time remaining to complete fluid administration at the set flow rate, remaining volume to be infused or administered to the patient, and the total volume remaining in the reservoir. Displayed also is a line representing the administered fluid's flow in a clear plastic tubing from the fluid's reservoir to its administered location on the patient's vascular system within the cardiovascular display. This line has a similar color to the fluid's color (e.g., gray for IV saline solution, red for blood) and connects between each administered fluid reservoir and its administered location on the patient's vascular system within the cardiovascular display. The fluid line can be animated to show the fluid flowing in the plastic tubing from its reservoir bag to its administered location on the patient's vascular system within the cardiovascular display. Higher fluid flow rate is represented by a fluid line moving at a faster rate. A measurement of the fluid's administration flow rate is displayed on the fluid's reservoir and/or anywhere on the fluid line connecting between the fluid's reservoir and its administered location on the patient's vascular system within the cardiovascular display. Mapped onto the fluid administration flow rate value is the fluid's flow rate control or regulator. The user can control and adjust the fluid's flow rate by manipulating its flow control or regulator to increase or decrease the fluid flow rate value. In this flow rate control, the user can move the flow rate value indicator from the current flow rate value to the desired flow rate value.

When several fluids are being administered to the patient, a Total Inflow Rate (TIFR) value is calculated and displayed by the system. For each of the administered fluids, a first fluid line connects between the fluid's reservoir and the TIFR value, while a second fluid line connects between the TIFR value and the fluids' administered location on the patient's vascular system within the cardiovascular display. The first and second fluids lines for each of the administered fluids can be animated as described above to graphically show the fluid's flow rate. For each of the administered fluids, a measurement of the fluid's flow rate value is displayed on the fluid's reservoir and/or anywhere on the first fluid line connecting between its reservoir and the TIFR value. Mapped onto each of the fluid's flow rate value is the fluid's flow rate control or regulator. The user can control and adjust the fluid's flow rate by manipulating its flow control or regulator to increase or decrease the flow rate value. In this flow rate control, the user can move the flow rate value indicator from the current flow rate value to the desired flow rate value.

Each fluid being collected from the patient is represented graphically by displaying an image of the fluid's collection reservoir such as an image of a blood collection canister or a urine collection bag. On or adjacent to the image representing the fluid displayed is the fluid's name, collected volume, and collection flow rate. Displayed also is a line representing the collected fluid flowing in a plastic tubing from the fluid's source on the patient's vascular system within the cardiovascular display to its collection reservoir. This line has a similar color to the fluid's color (e.g., yellow for urine, red for blood) and connects between each collected fluid's source location on the patient's vascular system within the cardiovascular display and its collection reservoir. The fluid line can also be animated as described above to show the fluid flowing from its source location on the patient's vascular system within the cardiovascular display to its collection reservoir. Higher fluid flow rate is represented by a fluid line moving at a faster rate. For each of the fluids being collected from the patient, a measurement of the fluid's collection flow rate is displayed on the fluid's collection container and/or anywhere on the fluid line connecting between its source location on the vascular system within the cardiovascular display and its collection reservoir.

When several fluids are being collected from the patient, a Total Outflow Rate (TOFR) value is calculated and displayed by the system. For each of the collected fluids, a first fluid line connects between the fluids' collection source on the patient's vascular system within the cardiovascular display and the TOFR value, while a second fluid line connects between the TOFR value and the fluid's collection reservoir. The first and second fluid lines for collected fluids can be animated as described above to mimic and graphically represent the flow rate value for each of the collected fluids. For each of the collected fluids, a measurement of the fluid's collection flow rate value is displayed on the fluid's collection reservoir and/or anywhere on the first fluid line connecting between its collection source location on the patient's vascular system within the cardiovascular display and the TOFR value.

A patient dialysis management system 900 is also described and disclosed. The patient dialysis management system 900 can monitor, control and communicate (e.g., visually display or audibly sound) patient's dialysis treatment and status. The system can have a human-machine interface for monitoring and control of patient's dialysis, and capable of the creation of displays and controls, wherein such displays are collections of one or more displays that may be graphs showing mathematical relationships or graphical in nature, and wherein such controls are collections of one or more controls that may be used to control patient's dialysis using a touch screen, a mouse, keyboard, or any other human-machine interface control.

System Components

FIG. 9 illustrates that the management system 900 can have one or more direct subsystems 901, such as a monitoring system 902, a blood intravenous access system 903, a dialysis system 904, or combinations thereof. The management system 900 can be for management and control of patient's dialysis. Any or all of the direct subsystems can be directly attached to the patient 30, for example by one or more probes or intravenous access 908. Any or all of the direct subsystems can be controlled by a micro-processor executing a management algorithm 907. The management algorithm 907 can display information through a one-way or two-way (e. g., touch screen) visual display monitor 905 and/or speakers (e.g., output speakers and/or one or more microphones). The management algorithm 907 can receive instructions from a control 906 which can be a separate input device (e.g., a keyboard, mouse or joystick), an integrated input device (e.g., the touch screen on the display monitor 905), or combinations thereof. The user 20 can provide instructions to the management algorithm 907 through the control 906, which can be part of the display 905.

The direct subsystems 901 can be physically integrated with the management algorithm 907, the control 906, the display 905 or combinations thereof. For example, the direct subsystems 901, and the management algorithm 907, the control 906, the display 905 or combinations thereof can be in a unitary form factor, such as in a single case or container.

The management algorithm 907 can monitor and identify parameters transitioning from normal conditions or settings to abnormal conditions or settings and the possible consequences on system functions or goals including failures as a result of such parameters' transitions. The management algorithm 907 can highlight the abnormal parameters settings and system functions or goals that can be affected as a result of such parameters' transitions using color or visual or auditory alarms in order to make such parameters and system conditions more prominent and visible.

When system failures or abnormal system functions or conditions occur, the management algorithm 907 can identify root causes and parameters related to the failures or abnormal system functions or conditions. The management algorithm 907 can highlight the abnormal parameters settings and affected system functions or goals that were impacted using color or visual or auditory alarms in order to make such parameters and system conditions more prominent and visible.

When system parameters transition from normal conditions or settings to abnormal conditions or settings or when system failures or abnormal functions or conditions occur, the management algorithm 907 can automatically adjust parameters to prevent or correct abnormal system functions or failures and restore normal system functions.

Displays

FIG. 10 illustrates that the management system 900 can display a management display 1000 on the visual display monitor 905. The management display 1000 can have a dialysis system anatomical display 1100, a Urea Reduction Rate display 1200, a Urea Concentration display 1300, a Urea Reduction Ratio display 1400, a Fractional Urea Clearance display 1500, a Dialyzer Clearance display 1600, and Urea Reduction Ratio and Fractional Urea Clearance balance object display 1700, or combinations and/or pluralities thereof. The balance object display 1700 can alter in shape, reflecting a change of its components, Urea Reduction Ratio and Fractional Urea Clearance.

The management display 1000 can have text labels on the display, for example, the rate and ratio of urea reduction, concentration of urea, the arterial and venous blood flow rate, and the dialysate flow rate in the dialyzer which can be shown in the graphic object representations within the management display 1000. The management display 1000 can be animated to show different states in real-time. For example, the animation can include graphic object changes showing arterial and venous blood flow, dialysate flow, and dialysis pump motion.

FIG. 11 illustrates the dialysis system anatomical display 1100 which presents an anatomical or topological schematics showing the patient 30, the arterial blood flow out of the intravenous access 1101, the venous blood flow into the intravenous access 1102, the dialysis machine 1103, the dialyzer 1104, dialysate flow into the dialyzer 1105, arterial blood flow into the dialyzer 1106, the arterial blood pump 1107, arterial blood pressure 1108, venous blood pressure 1109, and arterial blood flow into the dialyzer pressure 1110. The display associates and integrates arterial blood flow out of the intravenous access 1101 and venous blood flow into the intravenous access 1102 with the Urea Concentration display 1300 using lines 1111 and 1112, respectively. The display associates and integrates arterial blood flow into the dialyzer 1106 and dialysate flow into the dialyzer 1105 with the Dialyzer Clearance (K) display 1600 using lines 1114 and 1113, respectively.

FIG. 12 illustrates the Urea Reduction Rate (QUR) display 1200 which calculates and presents information related to Total Urea Reduction (TUR) 1204 and Urea Reduction Rate (QUR) 1205. The display presents the dialysis treatment duration (t) 1201, arterial blood urea flow rate (QUBA) 1202, and venous blood urea flow rate (QUBV) 1203 and uses such information to calculate and present Total Urea Reduction (TUR) 1204 and Urea Reduction Rate (QUR) 1205 information in real time. The display associates and integrates arterial blood urea flow rate (QUBA) 1202 and venous blood urea flow rate (QUBV) 1203 calculated and presented on the Urea Concentration display 1300 using lines 1206 and 1207, respectively.

FIG. 13 illustrates the Urea Concentration display 1300. The display presents measured arterial blood flow rate (QBA) 1303, venous blood flow rate (QBV) 1304, arterial blood Urea Concentration (UBAC) 1301 and venous blood Urea Concentration (UBVC) 1302. The display calculates and presents arterial blood urea flow rate (QUBA) 1305 using arterial blood flow rate (QBA) 1303 and arterial blood Urea Concentration (UBAC) 1301. The display calculates and presents venous blood urea flow rate (QUBV) 1306 using venous blood flow rate (QBV) 1304 and venous blood Urea Concentration (UBVC) 1302. The display associates and integrates measured arterial blood flow rate (QBA) 1303 and venous blood flow rate (QBV) 1304 with the dialysis system anatomical display 1100 using lines 1311 and 1302, respectively which point to the flow and intravenous access location of arterial and venous blood on the patient 30. The display associates and integrates arterial blood urea flow rate (QUBA) 1305 and venous blood urea flow rate (QUBV) 1306 presented on the Urea Reduction Rate (QUR) display 1200 using lines 1309 and 1310, respectively. The display associates and integrates arterial blood Urea Concentration (UBAC) 1301 and venous blood Urea Concentration (UBVC) 1302 with the Urea Reduction Ratio (URR) display 1400 using lines 1307 and 1308, respectively.

FIG. 14 illustrates the Urea Reduction Ratio (URR) display 1400. The display presents measured arterial blood Urea Concentration (UBAC) 1401 and venous blood Urea Concentration (UBVC) 1402 and uses such information to calculate and present Urea Reduction Ratio (URR) 1403 information. The display associates and integrates arterial blood Urea Concentration (UBAC) 1401 and venous blood Urea Concentration (UBVC) 1402 with the Urea Concentration display 1300 using lines 1404 and 1405, respectively. The display associates and integrates Urea Reduction Ratio (URR) 1403 information with the Urea Reduction Ratio and Fractional Urea Clearance balance object display 1700 using line 1406.

FIG. 15 illustrates the Fractional Urea Clearance (Kt/V) display 1500. The display presents the dialysis treatment duration (t) 1501, Dialyzer Clearance (K) 1502, and patient's dry weight converted to water volume (V) 1503. The display calculates and presents Fractional Urea Clearance (Kt/V) 1504 information. The display associates and integrates Fractional Urea Clearance (Kt/V) 1504 information with the Urea Reduction Ratio and Fractional Urea Clearance balance object display 1700 using line 1506. The display associates and integrates the Dialyzer Clearance (K) 1502 information with the Dialyzer Clearance (K) display 1600 using line 1505.

FIG. 16 illustrates the Dialyzer Clearance (K) display 1600. The display presents the dialyzer efficiency (KOA) 1601, measured blood flow into the dialyzer (QB) 1602, and measured dialysate flow into the dialyzer (QD) 1603 and uses such information to calculate and present the Dialyzer Clearance (K) 1604 information. The display associates and integrates Dialyzer Clearance (K) 1604 information with the Fractional Urea Clearance (Kt/V) display 1500 using line 1607. The display associates and integrates measured blood flow into the dialyzer (QB) 1602 and measured dialysate flow into the dialyzer (QD) 1603 with the dialyzer anatomical object on the dialysis system anatomical display 1100 using lines 1606 and 1605, respectively.

FIG. 17 illustrates the Urea Reduction Ratio and Fractional Urea Clearance balance object display 1700. The display presents Urea Reduction Ratio (URR) 1702 and Fractional Urea Clearance (Kt/V) 1701 in an object display which allows comparison and easy detection of balance between Urea Reduction Ratio (URR) 1702 and Fractional Urea Clearance (Kt/V) 1701 information. The display associates and integrates Urea Reduction Ratio (URR) 1702 information with the Urea Reduction Ratio (URR) display 1400 using line 1704. The display associates and integrates Fractional Urea Clearance (Kt/V) 1701 information with the Fractional Urea Clearance (Kt/V) display 1500 using line 1703.

Any labels shown or other text data shown on the display can be shown on, in, or adjacent to the representative graphic to which that label or text data is associated. Exemplary labels and text data are shown throughout the figures for illustrative purposes.

Any combinations or pluralities of elements herein are disclosed. The descriptions herein are exemplary and not intended to be limiting in any way. 

I claim:
 1. A method for displaying integrated graphics for diagnostics and control of patient's physiology, the method comprising: displaying a cardiac graphic object representing cardiac performance, said cardiac graphic object including at least a first, second, and third physiological parameter; displaying at least one dynamic graphical line from the first physiological parameter being displayed to the second physiological parameter being displayed, and wherein the displaying of the dynamic graphical line comprises illustrating at least one functional relationship between the first and second physiological parameters; identifying root causes of failures or suboptimal conditions and their related parameters or functions and the parameters or functions affected by such failures and highlighting root causes of failures or suboptimal conditions and their related parameters or functions and the parameters or functions affected by such failures using alarms, color, text or other format; providing recommendations for corrective actions to correct failures and their root causes and to restore normal functions of patient's cardiovascular system, pulmonary system, medications administration, and fluids management; and controlling system functions or parameters comprising at least one of medication administration flow rate or medication administration duration setting, fluids administration flow rate or fluids administration duration setting, ventilator setting, oxygen delivery flow rate or concentration, or CO2 removal setting to restore normal functions of patient's cardiovascular system, pulmonary system, medications administration, and fluids management.
 2. The method of claim 1, further comprising displaying a pulmonary graphic object representing pulmonary performance, wherein displaying the pulmonary graphic object comprises displaying pulmonary vascular blood flow, and wherein the displaying the pulmonary vascular blood flow comprises displaying at least one measurement based on the patient's pulmonary arterial blood pressure and at least one measurement based on the patient's pulmonary venous blood pressure, and at least one measurement based on the patient's pulmonary vascular resistance.
 3. The method of claim 1, further comprising displaying a systemic vascular graphic object representing systemic cardiovascular performance, wherein displaying the systemic vascular graphic object comprises displaying systemic vascular blood flow, wherein the displaying the systemic vascular blood flow comprises displaying at least one measurement based on the patient's systemic arterial blood pressure and at least one measurement based on the patient's systemic venous blood pressure, and at least one measurement based on the patient's systemic vascular resistance.
 4. The method of claim 1, wherein displaying the cardiac graphic object comprises displaying cardiac output, and wherein the displaying the cardiac graphic output comprises displaying a graph displaying stroke volume and heart rate.
 5. The method of claim 4, wherein the graph displaying stroke volume comprises displaying a left ventricle stroke volume and a right ventricle stroke volume.
 6. The method of claim 1, further comprising displaying a physiologic performance target.
 7. The method of claim 6, further comprising displaying a physiologic performance target-controlled medication delivery correlated with the physiologic performance target.
 8. The method of claim 1, comprising displaying a contractility graphic object representing a contractility quotient based on a pre-load and/or contractility of the patient's heart.
 9. The method of claim 8, wherein the contractility graphic object represents the pre-load and/or contractility of the patient's heart correlated with a medication delivery.
 10. The method of claim 1, further comprising displaying a medication delivery and controlling a delivery of at least one medication to the patient through the display, wherein the controlling of the delivery of the at least one medication comprises automatically controlling the medication delivery by a processor.
 11. The method of claim 10, wherein the controlling of the delivery of the at least one medication comprises setting a physiological performance target.
 12. The method of claim 1, displaying a net fluid flow graphic representing fluid inflow to the patient and outflow from the patient, wherein displaying a net fluid flow graphic comprises displaying urine output and blood loss, and/or displaying blood flow input and intravenous fluid administration, and/or displaying a net fluid flow balance object display.
 13. The method of claim 12, further comprising controlling a delivery of blood or at least one intravenous fluid administration to the patient through the display, wherein the controlling of the delivery comprises automatically controlling the medication delivery by a processor.
 14. A method for displaying integrated graphics for diagnostics and control of patient's ventilation, the method comprising: displaying a ventilation graphic object representing ventilation performance based on at least one measurement from the patient's respiratory rate, tidal volume, inspiratory flow rate, inspiratory oxygen concentration, airway pressure, alveolar O₂ pressure or concentration, alveolar CO₂ pressure or concentration, ratio of partial pressure of alveolar oxygen to alveolar carbon dioxide, inspiratory time, or inspiratory-to-expiratory time ratio, said ventilation graphic object including at least a first, second, and third physiologic parameter; displaying at least one dynamic graphical line from the first physiological parameter being displayed to the second physiological parameter being displayed, and wherein the displaying of the at least one dynamic graphical line comprises illustrating at least one functional relationship between the first and second physiological parameters; identifying root causes of failures or suboptimal conditions and their related parameters or functions and the parameters or functions that may be affected by such failures and highlights root causes of failures or suboptimal conditions and their related parameters or functions and the parameters or functions that may be affected by such failures using alarms, color, text or other format; providing recommendations for corrective actions to correct failures and their root causes and to restore normal functions of patient's cardiovascular system, pulmonary system, medications administration, and fluids management; and controlling system functions or parameters comprising at least one of medication administration flow rate or medication administration duration setting, fluids administration flow rate or fluids administration duration setting, ventilator setting, oxygen delivery flow rate or concentration, or CO2 removal setting to restore normal functions of patient's cardiovascular system, pulmonary system, medications administration, and fluids management.
 15. The method of claim 14, further comprising displaying a pulmonary graphic object representing pulmonary performance, wherein displaying the pulmonary graphic object comprises displaying pulmonary vascular blood flow, and wherein the displaying the pulmonary vascular blood flow comprises displaying at least one measurement based on the patient's pulmonary arterial blood pressure and at least one measurement based on the patient's pulmonary venous blood pressure, and at least one measurement based on the patient's pulmonary vascular resistance.
 16. The method of claim 15, wherein the pulmonary graphic object comprises an animated graphic.
 17. The method of claim 15, wherein displaying the pulmonary graphic object comprises displaying a ventilation performance.
 18. The method of claim 17, wherein displaying a ventilation performance comprises displaying a measurement of tidal volume, and/or alveolar oxygen concentration, and/or inspired oxygen concentration, alveolar CO2 concentration, and/or expired CO2 concentration, and/or minute ventilation, and/or a ratio of partial pressure of alveolar oxygen to alveolar carbon dioxide, and/or respiratory rate, and/or inspiratory flow rate, and/or inspiratory time, and/or inspiratory-to-expiratory time ratio, and/or positive inspiratory pressure.
 19. The method of claim 14, wherein the displaying of the ventilation graphic object comprises displaying an anatomical graphical representation of the ventilation system.
 20. The method of claim 14, further comprising displaying an oxygenation graphic object representing oxygenation based on at least one measurement from patient's systemic oxygenation performance, said oxygenation graphic object: displaying a systemic oxygenation graphic object representing systemic oxygenation performance, wherein displaying the systemic oxygenation graphic object comprises displaying systemic arterial oxygen flow rate (SAO₂FR), and wherein the displaying the systemic arterial oxygen flow rate comprises displaying at least one measurement based on the patient's systemic vascular blood flow and at least one measurement based on the patient's systemic arterial oxygen content (SAO₂C), systemic arterial oxygen saturation (SaO₂SAT), or systemic arterial oxygen pressure (PaO₂); displaying a systemic oxygenation graphic object representing systemic oxygenation performance, wherein displaying the systemic oxygenation graphic object comprises displaying systemic venous oxygen flow rate (SVO₂FR), and wherein the displaying the systemic venous oxygen flow rate comprises displaying at least one measurement based on the patient's systemic vascular blood flow and at least one measurement based on the patient's systemic venous oxygen content (SVO₂C), systemic venous oxygen saturation (SaO₂SAT), or systemic venous oxygen pressure (PvO₂); and displaying an Oxygen Consumption graphic object representing systemic oxygenation performance, wherein displaying the Oxygen Consumption graphic object comprises displaying at least one measurement based on systemic arterial oxygen flow rate (SAO₂FR) and at least one measurement based on the patient's systemic venous oxygen flow rate (SVO₂FR).
 21. The method of claim 14, further comprising displaying an oxygenation graphic object representing oxygenation based on at least one measurement from patient's pulmonary oxygenation performance, said oxygenation graphic object: displaying a pulmonary oxygenation graphic object representing pulmonary oxygenation performance, wherein displaying the pulmonary oxygenation graphic object comprises displaying pulmonary arterial oxygen flow rate (PAO₂FR), and wherein the displaying the pulmonary arterial oxygen flow rate comprises displaying at least one measurement based on the patient's pulmonary vascular blood flow and at least one measurement based on the patient's pulmonary arterial oxygen content (PAO₂C) or pulmonary arterial oxygen pressures (PaO₂); displaying a pulmonary oxygenation graphic object representing pulmonary oxygenation performance, wherein displaying the pulmonary oxygenation graphic object comprises displaying pulmonary venous oxygen flow rate (PVO₂FR), and wherein the displaying the pulmonary venous oxygen flow rate comprises displaying at least one measurement based on the patient's pulmonary vascular blood flow and at least one measurement based on the patient's pulmonary venous oxygen content (PVO₂C) or pulmonary venous oxygen pressures (PvO₂); and displaying a Blood Oxygenation graphic object representing pulmonary oxygenation performance, wherein displaying the Blood Oxygenation graphic object comprises displaying at least one measurement based on pulmonary arterial oxygen flow rate (PAO₂FR) and at least one measurement based on the patient's pulmonary venous oxygen flow rate (PVO₂FR).
 22. The method of claim 14, further comprising displaying a systemic carbon dioxide graphic object representing systemic carbon dioxide performance based on at least one measurement from patient's systemic carbon dioxide, said systemic carbon dioxide graphic object: displaying a systemic carbon dioxide graphic object representing systemic carbon dioxide, wherein displaying the systemic carbon dioxide graphic object comprises displaying systemic arterial carbon dioxide flow rate (SACO₂FR), and wherein the displaying the systemic arterial carbon dioxide flow rate comprises displaying at least one measurement based on the patient's systemic vascular blood flow and at least one measurement based on the patient's systemic arterial carbon dioxide content (SACO₂C) or systemic arterial CO₂ pressure (PaCO₂); displaying a systemic carbon dioxide graphic object representing systemic carbon dioxide, wherein displaying the systemic carbon dioxide graphic object comprises displaying systemic venous carbon dioxide flow rate (SVCO₂FR), and wherein the displaying the systemic venous carbon dioxide flow rate comprises displaying at least one measurement based on the patient's systemic vascular blood flow and at least one measurement based on the patient's systemic venous carbon dioxide content (SVO₂C) or systemic venous CO₂ pressure (PvCO₂); and displaying a carbon dioxide production graphic object representing systemic carbon dioxide, wherein displaying the carbon dioxide production graphic object comprises displaying at least one measurement based on systemic arterial carbon dioxide flow rate (SACO₂FR) and at least one measurement based on the patient's systemic venous carbon dioxide flow rate (SVCO₂FR).
 23. The method of claim 14, further comprising displaying a pulmonary carbon dioxide graphic object representing pulmonary carbon dioxide performance based on at least one measurement from patient's pulmonary carbon dioxide, said pulmonary carbon dioxide graphic object: displaying a pulmonary carbon dioxide graphic object representing pulmonary carbon dioxide, wherein displaying the pulmonary carbon dioxide graphic object comprises displaying pulmonary arterial carbon dioxide flow rate (PACO₂FR), and wherein the displaying the pulmonary arterial carbon dioxide flow rate comprises displaying at least one measurement based on the patient's pulmonary vascular blood flow and at least one measurement based on the patient's pulmonary arterial carbon dioxide content (PACO₂C) or pulmonary arterial CO₂ pressure (PaCO₂); displaying a pulmonary carbon dioxide graphic object representing pulmonary carbon dioxide, wherein displaying the pulmonary carbon dioxide graphic object comprises displaying pulmonary venous carbon dioxide flow rate (PVCO₂FR), and wherein the displaying the pulmonary venous carbon dioxide flow rate comprises displaying at least one measurement based on the patient's pulmonary vascular blood flow and at least one measurement based on the patient's pulmonary venous carbon dioxide content (PVCO₂C) or pulmonary venous CO₂ pressures (PaCO₂); and displaying a carbon dioxide elimination graphic object representing pulmonary carbon dioxide, wherein displaying the carbon dioxide elimination graphic object comprises displaying at least one measurement based on pulmonary arterial carbon dioxide flow rate (PACO₂FR) and at least one measurement based on the patient's pulmonary venous carbon dioxide flow rate (PVCO₂FR).
 24. The method of claim 14, further comprising displaying oxygenation balance graphic object, wherein displaying oxygenation balance graphic comprises displaying oxygen consumption, and/or displaying blood oxygenation, and/or displaying a balance between oxygen consumption and blood oxygenation in an object display.
 25. The method of claim 14, further comprising displaying CO₂ balance graphic object, wherein displaying CO₂ balance graphic comprises displaying CO₂ production, and/or displaying CO₂ elimination, and/or displaying a balance between CO₂ production and CO₂ elimination in an object display.
 26. The method of claim 14, further comprising displaying a physiologic performance target.
 27. The method of claim 26, further comprising displaying a physiologic performance target-controlled medication delivery correlated with the physiologic performance target.
 28. The method of claim 14, further comprising displaying a medication delivery and controlling a delivery of at least one medication to the patient through the display, wherein the controlling of the delivery of the at least one medication comprises automatically controlling the medication delivery by a processor and setting a physiological performance target.
 29. The method of claim 28, wherein the controlling of the delivery of the at least one medication comprises setting a physiological performance target.
 30. The method of claim 14, displaying a net fluid flow graphic representing fluid inflow to the patient and outflow from the patient, wherein displaying a net fluid flow graphic comprises displaying urine output and blood loss, and/or displaying blood flow input and intravenous fluid administration, and/or displaying a net fluid flow balance object display.
 31. The method of claim 30, further comprising controlling a delivery of blood or at least one intravenous fluid administration to the patient through the display, wherein the controlling of the delivery comprises automatically controlling the medication delivery by a processor.
 32. A method for displaying integrated graphics for control and diagnostics of patient's physiology, the method comprising: displaying a ventilation graphic object representing ventilation performance based on at least one measurement from the patient's ventilation performance, said ventilation graphic object including at least a first, second, and third physiologic parameter; displaying a cardiac graphic object representing cardiac performance based on at least one measurement from the patient's cardiac performance, said cardiac graphic object including at least a first, second, and third physiologic parameter; displaying at least one dynamic graphical line from the first physiological parameter being displayed to the second physiological parameter being displayed, and wherein the displaying of the at least one dynamic graphical line comprises illustrating at least one functional relationship between the first and second physiological parameters; wherein the displaying of the cardiac graphic object comprises displaying an anatomical graphical representation of the heart, and wherein the anatomical graphical representation of the heart is animated to represent the anatomical graphical representation of the heart contracting and expanding at a measured heart contractility value; displaying an anatomical graphical representation of the cardiovascular vessels, and wherein the anatomical graphical representation of the cardiovascular vessels is animated to represent the anatomical graphical representation of the cardiovascular vessels expanding or increasing in diameter during a decrease of vascular resistance and contracting or decreasing in diameter during an increase in vascular resistance; wherein the displaying of the ventilation graphic object comprises displaying an anatomical graphical representation of the ventilation system, and wherein the anatomical graphical representation of the ventilation system is animated and expands and contracts at a measured respiratory rate value; identifying root causes of failures or suboptimal conditions and their related parameters or functions and the parameters or functions that are affected by such failures and highlights root causes of failures or suboptimal conditions and their related parameters or functions and the parameters or functions that are affected by such failures using alarms, color, text or other format; providing recommendations for corrective actions to correct failures and their root causes and to restore normal functions of patient's cardiovascular system, pulmonary system, medications administration, and fluids management; and controlling system functions or parameters comprising at least one of medication administration flow rate or medication administration duration setting, fluids administration flow rate or fluids administration duration setting, ventilator setting, oxygen delivery flow rate or concentration, or CO2 removal setting to restore normal functions of patient's cardiovascular system, pulmonary system, medications administration, and fluids management. 